The immunology and genetics of resistance of sheep to Teladorsagia circumcincta
نویسندگان
چکیده
منابع مشابه
Variable exon usage of differentially-expressed genes associated with resistance of sheep to Teladorsagia circumcincta
The resistance and susceptibility of sheep to the common abomasal nematode parasite, Teladorsagia circumcincta is strongly associated with the differential polarization of the immune response. Resistant animals control larval colonization by the production of a protective antibody response regulated by Th2 T cells. Susceptible sheep respond to infection by developing an inflammatory Th1/Th17 re...
متن کاملRegulation of Teladorsagia circumcincta and Trichostrongylus colubriformis worm populations by grazing sheep with differing resistance status.
In an experiment lasting 4 years, changes in the Teladorsagia circumcincta and Trichostrongylus colubriformis populations were compared in lambs and adult sheep with differing resistance statuses. Two flocks of 30 rams (resistant R and susceptible S) grazed separate pastures and 8 rams were slaughtered in the middle and at the end of each grazing season. Five groups of tracer lambs were added e...
متن کاملSelection and characterisation of monepantel resistance in Teladorsagia circumcincta isolates
Monepantel (MPTL) is one of two new anthelmintic compounds introduced onto the sheep market to control gastro-intestinal nematodes. Resistance to this compound is rare but has been reported. In order to preserve the efficacy of this and other anthelmintics, it is essential to understand both (a) the mechanisms involved in the selection of resistance and (b) how the parasites evolve to deal with...
متن کاملThe dynamic influence of the DRB1*1101 allele on the resistance of sheep to experimental Teladorsagia circumcincta infection
Suffolk sheep carrying the DRB1*1101 (previously referred to as-DRB1*0203 or G2) allele have been reported to show increased resistance to natural Teladorsagia circumcincta infection compared to non-carriers. The objective of this study was to compare the biochemical and physiological responses of DRB1*1101 carrier and non-carrier twin lambs to an experimental infection with 3 × 10(4) L3 Telado...
متن کاملShort Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells and globule leukocytes in the abomasum, and that all three of these parameters are negatively ass...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Veterinary Research Communications
سال: 2013
ISSN: 0165-7380,1573-7446
DOI: 10.1007/s11259-013-9559-9